Assay Detail
Functional
CHEMBL870098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human polymorphonuclear leukocyte
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.40 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377821 | — | — | 1 | 9.30 |
| CHEMBL205800 | — | — | 1 | 9.30 |
| CHEMBL377094 | — | — | 1 | 9.10 |
| CHEMBL204365 | — | — | 1 | 9.05 |
| CHEMBL205189 | — | — | 1 | 8.72 |
| CHEMBL207057 | — | — | 1 | 8.64 |
| CHEMBL205222 | — | — | 1 | 8.57 |
| CHEMBL207109 | — | — | 1 | 8.52 |
| CHEMBL204633 | — | — | 1 | 8.43 |
| CHEMBL204781 | — | — | 1 | 8.43 |
| CHEMBL206632 | — | — | 1 | 8.37 |
| CHEMBL204890 | — | — | 1 | 7.94 |
| CHEMBL380473 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377821 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL205800 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL377094 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL204365 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL205189 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL207057 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL205222 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL207109 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL204633 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL204781 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL206632 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL204890 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL380473 | — | IC50 | = | 17000.0 | nM | 4.77 |