Assay Detail
Functional
CHEMBL870099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human whole blood
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.79 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207057 | — | — | 1 | 7.44 |
| CHEMBL207109 | — | — | 1 | 7.32 |
| CHEMBL377094 | — | — | 1 | 7.28 |
| CHEMBL205800 | — | — | 1 | 7.16 |
| CHEMBL377821 | — | — | 1 | 7.06 |
| CHEMBL204365 | — | — | 1 | 7.05 |
| CHEMBL205189 | — | — | 1 | 6.82 |
| CHEMBL204633 | — | — | 1 | 6.44 |
| CHEMBL206632 | — | — | 1 | 6.40 |
| CHEMBL205222 | — | — | 1 | 6.40 |
| CHEMBL204781 | — | — | 1 | 6.36 |
| CHEMBL204890 | — | — | 1 | 5.77 |
| CHEMBL380473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207057 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL207109 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL377094 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL205800 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL377821 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL204365 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL205189 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL204633 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL206632 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL205222 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL204781 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL204890 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL380473 | — | IC50 | - | — | - |