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Assay Detail

CHEMBL870169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Activity at LXR alpha as beta-lactamase transactivation in CHO cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxysterols receptor LXR-alpha (CHEMBL2808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

SAR studies: designing potent and selective LXR agonists.
Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD.
Bioorg Med Chem Lett (2006) 16 : 3055 -3060
PubMed 16529931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 5.87 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL208967 1 6.77
CHEMBL207690 1 6.75
CHEMBL207019 1 6.35
CHEMBL210917 1 6.32
CHEMBL378074 1 6.27
CHEMBL383728 1 6.23
CHEMBL210990 1 6.21
CHEMBL207907 1 6.09
CHEMBL381064 1 5.96
CHEMBL427040 1 5.89
CHEMBL377218 1 5.72
CHEMBL208567 1 5.64
CHEMBL207442 1 5.58
CHEMBL207382 1 5.52
CHEMBL382789 1 5.44
CHEMBL207188 1 5.30
CHEMBL23296 1 5.23
CHEMBL207142 1 5.22
CHEMBL207103 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL208967 EC50 = 170.0 nM 6.77
CHEMBL207690 EC50 = 180.0 nM 6.75
CHEMBL207019 EC50 = 450.0 nM 6.35
CHEMBL210917 EC50 = 480.0 nM 6.32
CHEMBL378074 EC50 = 540.0 nM 6.27
CHEMBL383728 EC50 = 590.0 nM 6.23
CHEMBL210990 EC50 = 620.0 nM 6.21
CHEMBL207907 EC50 = 820.0 nM 6.09
CHEMBL381064 EC50 = 1100.0 nM 5.96
CHEMBL427040 EC50 = 1300.0 nM 5.89
CHEMBL377218 EC50 = 1900.0 nM 5.72
CHEMBL208567 EC50 = 2300.0 nM 5.64
CHEMBL207442 EC50 = 2600.0 nM 5.58
CHEMBL207382 EC50 = 3000.0 nM 5.52
CHEMBL382789 EC50 = 3600.0 nM 5.44
CHEMBL207188 EC50 = 5000.0 nM 5.30
CHEMBL23296 EC50 = 5900.0 nM 5.23
CHEMBL207142 EC50 = 6000.0 nM 5.22
CHEMBL207103 EC50 = 8000.0 nM 5.10