Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL870175

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PPAR alpha
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor alpha (CHEMBL239)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

SAR studies: designing potent and selective LXR agonists.
Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD.
Bioorg Med Chem Lett (2006) 16 : 3055 -3060
PubMed 16529931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.34 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL207103 1 7.80
CHEMBL210973 1 7.72
CHEMBL382789 1 6.85
CHEMBL210768 1 6.64
CHEMBL23296 1 6.55
CHEMBL207019 1 6.51
CHEMBL383728 1 6.40
CHEMBL207907 1 6.35
CHEMBL209563 1 6.22
CHEMBL210917 1 6.11
CHEMBL427040 1 6.06
CHEMBL207442 1 5.82
CHEMBL208711 1 5.58
CHEMBL208567 1 5.36
CHEMBL377218 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL207103 IC50 = 16.0 nM 7.80
CHEMBL210973 IC50 = 19.0 nM 7.72
CHEMBL382789 IC50 = 140.0 nM 6.85
CHEMBL210768 IC50 = 230.0 nM 6.64
CHEMBL23296 IC50 = 280.0 nM 6.55
CHEMBL207019 IC50 = 310.0 nM 6.51
CHEMBL383728 IC50 = 400.0 nM 6.40
CHEMBL207907 IC50 = 450.0 nM 6.35
CHEMBL209563 IC50 = 600.0 nM 6.22
CHEMBL210917 IC50 = 780.0 nM 6.11
CHEMBL427040 IC50 = 870.0 nM 6.06
CHEMBL207442 IC50 = 1500.0 nM 5.82
CHEMBL208711 IC50 = 2600.0 nM 5.58
CHEMBL208567 IC50 = 4400.0 nM 5.36
CHEMBL377218 IC50 = 8300.0 nM 5.08