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Assay Detail

CHEMBL870176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PPAR delta
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

SAR studies: designing potent and selective LXR agonists.
Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD.
Bioorg Med Chem Lett (2006) 16 : 3055 -3060
PubMed 16529931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.01 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL210768 1 8.40
CHEMBL23296 1 8.40
CHEMBL210973 1 8.10
CHEMBL210917 1 7.62
CHEMBL209563 1 7.41
CHEMBL383646 1 7.31
CHEMBL383728 1 7.24
CHEMBL207907 1 7.16
CHEMBL208567 1 7.10
CHEMBL207103 1 7.06
CHEMBL207442 1 7.03
CHEMBL427040 1 6.82
CHEMBL207019 1 6.51
CHEMBL382789 1 6.27
CHEMBL208967 1 5.85
CHEMBL210613 1 5.75
CHEMBL208711 1 5.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL210768 IC50 = 4.0 nM 8.40
CHEMBL23296 IC50 = 4.0 nM 8.40
CHEMBL210973 IC50 = 8.0 nM 8.10
CHEMBL210917 IC50 = 24.0 nM 7.62
CHEMBL209563 IC50 = 39.0 nM 7.41
CHEMBL383646 IC50 = 49.0 nM 7.31
CHEMBL383728 IC50 = 57.0 nM 7.24
CHEMBL207907 IC50 = 70.0 nM 7.16
CHEMBL208567 IC50 = 79.0 nM 7.10
CHEMBL207103 IC50 = 88.0 nM 7.06
CHEMBL207442 IC50 = 93.0 nM 7.03
CHEMBL427040 IC50 = 150.0 nM 6.82
CHEMBL207019 IC50 = 310.0 nM 6.51
CHEMBL382789 IC50 = 540.0 nM 6.27
CHEMBL208967 IC50 = 1400.0 nM 5.85
CHEMBL210613 IC50 = 1800.0 nM 5.75
CHEMBL208711 IC50 = 8600.0 nM 5.07