Assay Detail
Functional
CHEMBL870195
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Antiproliferative activity against bovine BMEC
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | BMEC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel combretastatin analogues endowed with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.68 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.43 |
| CHEMBL209070 | — | — | 1 | 7.64 |
| CHEMBL208559 | — | — | 1 | 7.55 |
| CHEMBL210722 | — | — | 1 | 7.31 |
| CHEMBL210392 | — | — | 1 | 7.27 |
| CHEMBL378110 | — | — | 1 | 7.25 |
| CHEMBL210806 | — | — | 1 | 7.06 |
| CHEMBL210335 | — | — | 1 | 7.03 |
| CHEMBL379473 | — | — | 1 | 6.47 |
| CHEMBL208258 | — | — | 1 | 6.46 |
| CHEMBL382453 | — | — | 1 | 6.19 |
| CHEMBL379070 | — | — | 1 | 6.17 |
| CHEMBL378407 | — | — | 1 | 6.08 |
| CHEMBL208949 | — | — | 1 | 5.72 |
| CHEMBL210680 | — | — | 1 | 5.12 |
| CHEMBL378126 | — | — | 1 | 5.09 |
| CHEMBL210440 | — | — | 1 | 5.08 |
| CHEMBL207470 | — | — | 1 | 5.00 |
| CHEMBL210792 | — | — | 1 | 4.91 |
| CHEMBL378813 | — | — | 1 | 4.70 |
| CHEMBL209340 | — | — | 1 | 4.64 |
| CHEMBL209237 | — | — | 1 | 4.61 |
| CHEMBL206931 | — | — | 1 | 4.56 |
| CHEMBL206970 | — | — | 1 | 4.50 |
| CHEMBL210406 | — | — | 1 | 4.42 |
| CHEMBL379620 | — | — | 1 | 4.41 |
| CHEMBL210679 | — | — | 1 | 4.28 |
| CHEMBL210281 | — | — | 1 | 4.25 |
| CHEMBL208134 | — | — | 1 | 4.16 |
| CHEMBL427224 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL209070 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL208559 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL210722 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL210392 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL378110 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL210806 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL210335 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL379473 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL208258 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL382453 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL379070 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL378407 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL208949 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL210680 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL378126 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL210440 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL207470 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL210792 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL378813 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL209340 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL209237 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL206931 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL206970 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL210406 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL379620 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL210679 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL210281 | — | IC50 | = | 56400.0 | nM | 4.25 |
| CHEMBL208134 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL427224 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL210727 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL210220 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL210221 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL379815 | — | IC50 | > | 20000.0 | nM | - |