Assay Detail
Binding
CHEMBL870326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.20 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369722 | Demotensin 1 | — | 1 | 9.49 |
| CHEMBL1791383 | DEMOTENSIN 2 | — | 1 | 9.39 |
| CHEMBL407196 | NEUROTENSIN | — | 1 | 9.21 |
| CHEMBL375002 | DEMOTENSIN 4 | — | 1 | 9.07 |
| CHEMBL219862 | DEMOTENSIN 3 | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369722 | Demotensin 1 | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1791383 | DEMOTENSIN 2 | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL407196 | NEUROTENSIN | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL375002 | DEMOTENSIN 4 | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL219862 | DEMOTENSIN 3 | IC50 | = | 1.5 | nM | 8.82 |