Assay Detail
Binding
CHEMBL870381
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Inhibition of PDE6
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.27 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.40 |
| CHEMBL213060 | — | — | 1 | 7.21 |
| CHEMBL212397 | — | — | 1 | 6.55 |
| CHEMBL377563 | — | — | 1 | 6.48 |
| CHEMBL378255 | — | — | 1 | 6.48 |
| CHEMBL213219 | — | — | 1 | 6.26 |
| CHEMBL438451 | — | — | 1 | 6.21 |
| CHEMBL213425 | — | — | 1 | 6.07 |
| CHEMBL377144 | — | — | 1 | 6.00 |
| CHEMBL213113 | — | — | 1 | 5.66 |
| CHEMBL213265 | — | — | 1 | 5.58 |
| CHEMBL213094 | — | — | 1 | 5.33 |
| CHEMBL215503 | — | — | 1 | - |
| CHEMBL215268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL213060 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL212397 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL377563 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL378255 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL213219 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL438451 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL213425 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL377144 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL213113 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL213265 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL213094 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL215503 | — | IC50 | - | — | - | |
| CHEMBL215268 | — | IC50 | - | — | - |