Assay Detail
Binding
CHEMBL870417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.41 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58646 | — | — | 1 | 10.22 |
| CHEMBL210005 | — | — | 1 | 9.46 |
| CHEMBL60869 | — | — | 1 | 9.33 |
| CHEMBL214104 | — | — | 1 | 8.89 |
| CHEMBL209550 | — | — | 1 | 8.77 |
| CHEMBL377789 | — | — | 1 | 8.74 |
| CHEMBL212434 | — | — | 1 | 8.57 |
| CHEMBL213291 | — | — | 1 | 8.52 |
| CHEMBL378355 | — | — | 1 | 8.07 |
| CHEMBL215594 | — | — | 1 | 7.96 |
| CHEMBL1162933 | — | — | 1 | 7.58 |
| CHEMBL215760 | — | — | 1 | 7.57 |
| CHEMBL213880 | — | — | 1 | 7.44 |
| CHEMBL293103 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58646 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL210005 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL60869 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL214104 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL209550 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL377789 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL212434 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL213291 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL378355 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL215594 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1162933 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL215760 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL213880 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL293103 | — | Ki | = | 270.0 | nM | 6.57 |