Assay Detail
Functional
CHEMBL870549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | MTC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Extracellular calcium-sensing receptor (CHEMBL2516) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.84 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180672 | — | — | 1 | 6.28 |
| CHEMBL199716 | — | — | 1 | 5.66 |
| CHEMBL199495 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180672 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL199716 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL199495 | — | IC50 | = | 2560.0 | nM | 5.59 |