Assay Detail
Binding
CHEMBL870697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant MMP3
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.68 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72511 | — | — | 1 | 9.05 |
| CHEMBL382705 | — | — | 1 | 8.30 |
| CHEMBL207756 | — | — | 1 | 7.96 |
| CHEMBL208181 | — | — | 1 | 7.92 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 7.25 |
| CHEMBL438964 | — | — | 1 | 6.73 |
| CHEMBL206875 | — | — | 1 | 6.52 |
| CHEMBL439330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72511 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL382705 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL207756 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL208181 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL115653 | CIPEMASTAT | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL438964 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL206875 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL439330 | — | Ki | - | — | - |