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Assay Detail

CHEMBL870734

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HSP90 by FP assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Heat shock protein HSP90 (CHEMBL2095165)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

4-Amino derivatives of the Hsp90 inhibitor CCT018159.
Barril X, Beswick MC, Collier A, Drysdale MJ, Dymock BW, Fink A, Grant K, Howes R, Jordan AM, Massey A, Surgenor A, Wayne J, Workman P, Wright L.
Bioorg Med Chem Lett (2006) 16 : 2543 -2548
PubMed 16480864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.37 6.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL399530 1 6.83
CHEMBL251974 1 6.22
CHEMBL207307 1 6.22
CHEMBL208239 1 6.13
CHEMBL109480 TANESPIMYCIN 3.0 1 5.81
CHEMBL380888 1 5.70
CHEMBL383262 1 5.62
CHEMBL207613 1 5.52
CHEMBL426848 1 5.37
CHEMBL377516 1 5.36
CHEMBL207757 1 5.28
CHEMBL204689 1 5.25
CHEMBL207352 1 5.07
CHEMBL205546 1 5.06
CHEMBL207701 1 5.02
CHEMBL206679 1 5.01
CHEMBL207397 1 4.86
CHEMBL377333 1 4.67
CHEMBL204784 1 4.66
CHEMBL437306 1 4.60
CHEMBL381772 1 4.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL399530 IC50 = 148.0 nM 6.83
CHEMBL251974 IC50 = 600.0 nM 6.22
CHEMBL207307 IC50 = 600.0 nM 6.22
CHEMBL208239 IC50 = 740.0 nM 6.13
CHEMBL109480 TANESPIMYCIN IC50 = 1540.0 nM 5.81
CHEMBL380888 IC50 = 2000.0 nM 5.70
CHEMBL383262 IC50 = 2400.0 nM 5.62
CHEMBL207613 IC50 = 3000.0 nM 5.52
CHEMBL426848 IC50 = 4300.0 nM 5.37
CHEMBL377516 IC50 = 4400.0 nM 5.36
CHEMBL207757 IC50 = 5200.0 nM 5.28
CHEMBL204689 IC50 = 5600.0 nM 5.25
CHEMBL207352 IC50 = 8500.0 nM 5.07
CHEMBL205546 IC50 = 8800.0 nM 5.06
CHEMBL207701 IC50 = 9500.0 nM 5.02
CHEMBL206679 IC50 = 9700.0 nM 5.01
CHEMBL207397 IC50 = 13900.0 nM 4.86
CHEMBL377333 IC50 = 21200.0 nM 4.67
CHEMBL204784 IC50 = 21700.0 nM 4.66
CHEMBL437306 IC50 = 25100.0 nM 4.60
CHEMBL381772 IC50 = 32600.0 nM 4.49