Assay Detail
Functional
CHEMBL870843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrs
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.56 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50344 | — | — | 1 | 6.77 |
| CHEMBL210378 | — | — | 1 | 6.17 |
| CHEMBL52765 | — | — | 1 | 6.17 |
| CHEMBL209343 | — | — | 1 | 6.05 |
| CHEMBL210660 | — | — | 1 | 5.94 |
| CHEMBL210444 | — | — | 1 | 5.87 |
| CHEMBL207009 | — | — | 1 | 5.75 |
| CHEMBL208594 | — | — | 1 | 5.68 |
| CHEMBL208240 | — | — | 1 | 5.68 |
| CHEMBL210893 | — | — | 1 | 5.51 |
| CHEMBL343352 | — | — | 1 | 5.48 |
| CHEMBL210659 | — | — | 1 | 5.27 |
| CHEMBL336113 | — | — | 1 | 5.19 |
| CHEMBL209818 | — | — | 1 | 5.16 |
| CHEMBL379047 | — | — | 1 | 4.96 |
| CHEMBL208849 | — | — | 1 | 4.93 |
| CHEMBL210502 | — | — | 1 | 4.91 |
| CHEMBL208144 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50344 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL210378 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL52765 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL209343 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL210660 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL210444 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL207009 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL208594 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL208240 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL210893 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL343352 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL210659 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL336113 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL209818 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL379047 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL208849 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL210502 | — | IC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL208144 | — | IC50 | = | 23030.0 | nM | 4.64 |