Assay Detail
Binding
CHEMBL870844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 60 | 7.02 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208824 | — | — | 1 | 9.00 |
| CHEMBL273807 | — | — | 1 | 8.70 |
| CHEMBL426504 | — | — | 1 | 8.30 |
| CHEMBL380176 | — | — | 1 | 8.05 |
| CHEMBL254725 | — | — | 1 | 7.96 |
| CHEMBL210808 | — | — | 1 | 7.89 |
| CHEMBL251869 | — | — | 1 | 7.85 |
| CHEMBL251870 | — | — | 1 | 7.85 |
| CHEMBL210938 | — | — | 1 | 7.75 |
| CHEMBL380284 | — | — | 1 | 7.75 |
| CHEMBL210271 | — | — | 1 | 7.72 |
| CHEMBL378652 | — | — | 1 | 7.70 |
| CHEMBL207434 | — | — | 1 | 7.70 |
| CHEMBL379474 | — | — | 1 | 7.66 |
| CHEMBL378598 | — | — | 1 | 7.66 |
| CHEMBL261722 | — | — | 1 | 7.57 |
| CHEMBL210649 | — | — | 1 | 7.55 |
| CHEMBL209174 | — | — | 1 | 7.54 |
| CHEMBL210747 | — | — | 1 | 7.48 |
| CHEMBL210150 | — | — | 1 | 7.47 |
| CHEMBL210212 | — | — | 1 | 7.46 |
| CHEMBL378570 | — | — | 1 | 7.44 |
| CHEMBL208110 | — | — | 1 | 7.43 |
| CHEMBL210683 | — | — | 1 | 7.43 |
| CHEMBL380219 | — | — | 1 | 7.43 |
| CHEMBL408186 | — | — | 1 | 7.42 |
| CHEMBL207524 | — | — | 1 | 7.40 |
| CHEMBL210609 | — | — | 1 | 7.36 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 7.25 |
| CHEMBL210213 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208824 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL273807 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL426504 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL380176 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL254725 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL210808 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL251869 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL251870 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL210938 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL380284 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL210271 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL378652 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL207434 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL378598 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL379474 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL261722 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL210649 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL209174 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL210747 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL210150 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL210212 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL378570 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL208110 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL210683 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL380219 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL408186 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL207524 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL210609 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL210213 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL209217 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL210319 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL210565 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL207482 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL208920 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL209831 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL208723 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL210614 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL210890 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL211038 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL210482 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL378020 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL379032 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL383201 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL378743 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL210738 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL441530 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL379838 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL437301 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL210389 | — | Ki | = | 3700.0 | nM | 5.43 |