Assay Detail
Binding
CHEMBL870913
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Inhibition of CYP19
19
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.58 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213588 | — | — | 2 | 7.35 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 7.28 |
| CHEMBL209731 | — | — | 2 | 7.16 |
| CHEMBL213587 | — | — | 2 | 7.15 |
| CHEMBL212473 | — | — | 2 | 7.10 |
| CHEMBL377766 | — | — | 2 | 6.36 |
| CHEMBL212168 | — | — | 2 | 6.33 |
| CHEMBL158635 | — | — | 2 | 6.26 |
| CHEMBL377626 | — | — | 2 | 5.75 |
| CHEMBL209047 | — | — | 2 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213588 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL213588 | — | IC50 | = | 44.67 | nM | 7.35 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL209731 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL209731 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL213587 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL213587 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL212473 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL212473 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL377766 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL377766 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL212168 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL212168 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL158635 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL158635 | — | IC50 | = | 549.54 | nM | 6.26 |
| CHEMBL377626 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL377626 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL209047 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL209047 | — | IC50 | = | 4100.0 | nM | 5.39 |