Assay Detail
Functional
CHEMBL870923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SHEP1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094132) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.11 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378349 | — | — | 1 | 6.73 |
| CHEMBL378471 | — | — | 1 | 6.24 |
| CHEMBL214268 | PHA-543613 | 1.0 | 1 | 6.20 |
| CHEMBL379302 | — | — | 1 | 6.02 |
| CHEMBL177611 | PNU-282987 | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378349 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL378471 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL214268 | PHA-543613 | Ki | = | 628.0 | nM | 6.20 |
| CHEMBL379302 | — | Ki | = | 962.0 | nM | 6.02 |
| CHEMBL177611 | PNU-282987 | Ki | = | 4540.0 | nM | 5.34 |