Assay Detail
Binding
CHEMBL870977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Lck in presence of 0.5 uM ATP by HTRF kinase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.71 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386760 | — | — | 1 | 9.22 |
| CHEMBL385898 | — | — | 1 | 9.00 |
| CHEMBL211460 | — | — | 1 | 9.00 |
| CHEMBL263769 | — | — | 1 | 9.00 |
| CHEMBL442485 | — | — | 1 | 9.00 |
| CHEMBL215289 | — | — | 1 | 9.00 |
| CHEMBL215730 | — | — | 1 | 9.00 |
| CHEMBL211845 | — | — | 1 | 9.00 |
| CHEMBL212721 | — | — | 1 | 9.00 |
| CHEMBL214775 | — | — | 1 | 9.00 |
| CHEMBL212668 | — | — | 1 | 9.00 |
| CHEMBL212143 | — | — | 1 | 9.00 |
| CHEMBL264803 | — | — | 1 | 9.00 |
| CHEMBL379733 | — | — | 1 | 9.00 |
| CHEMBL379080 | — | — | 1 | 9.00 |
| CHEMBL215411 | — | — | 1 | 8.70 |
| CHEMBL213100 | — | — | 1 | 8.70 |
| CHEMBL377481 | — | — | 1 | 8.00 |
| CHEMBL215847 | — | — | 1 | 7.92 |
| CHEMBL209908 | — | — | 1 | 7.89 |
| CHEMBL427047 | — | — | 1 | 7.85 |
| CHEMBL215726 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386760 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL385898 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL211460 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL263769 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL442485 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL215289 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL215730 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL211845 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212721 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL214775 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212668 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212143 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL264803 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL379733 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL379080 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL215411 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL213100 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL377481 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL215847 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL209908 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL427047 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL215726 | — | IC50 | = | 49.0 | nM | 7.31 |