Assay Detail
Binding
CHEMBL870978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Src
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442485 | — | — | 1 | 9.00 |
| CHEMBL212143 | — | — | 1 | 9.00 |
| CHEMBL385898 | — | — | 1 | 9.00 |
| CHEMBL386760 | — | — | 1 | 9.00 |
| CHEMBL379080 | — | — | 1 | 8.70 |
| CHEMBL264803 | — | — | 1 | 8.70 |
| CHEMBL215730 | — | — | 1 | 8.70 |
| CHEMBL211845 | — | — | 1 | 8.70 |
| CHEMBL215847 | — | — | 1 | 8.52 |
| CHEMBL211460 | — | — | 1 | 8.40 |
| CHEMBL214775 | — | — | 1 | 8.40 |
| CHEMBL212721 | — | — | 1 | 8.40 |
| CHEMBL215289 | — | — | 1 | 8.30 |
| CHEMBL212668 | — | — | 1 | 8.22 |
| CHEMBL213100 | — | — | 1 | 8.22 |
| CHEMBL379733 | — | — | 1 | 8.15 |
| CHEMBL427047 | — | — | 1 | 8.00 |
| CHEMBL215411 | — | — | 1 | 7.92 |
| CHEMBL263769 | — | — | 1 | 7.89 |
| CHEMBL377481 | — | — | 1 | 7.85 |
| CHEMBL209908 | — | — | 1 | 7.01 |
| CHEMBL215726 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442485 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212143 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL385898 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL386760 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL379080 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL264803 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL215730 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL211845 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL215847 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL211460 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL214775 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL212721 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL215289 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL212668 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL213100 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL379733 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL427047 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL215411 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL263769 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL377481 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL209908 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL215726 | — | IC50 | = | 500.0 | nM | 6.30 |