Assay Detail
Binding
CHEMBL870980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.48 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377481 | — | — | 1 | 6.89 |
| CHEMBL386760 | — | — | 1 | 6.85 |
| CHEMBL215730 | — | — | 1 | 6.85 |
| CHEMBL264803 | — | — | 1 | 6.77 |
| CHEMBL385898 | — | — | 1 | 6.77 |
| CHEMBL427047 | — | — | 1 | 6.72 |
| CHEMBL211460 | — | — | 1 | 6.72 |
| CHEMBL442485 | — | — | 1 | 6.70 |
| CHEMBL379080 | — | — | 1 | 6.68 |
| CHEMBL212721 | — | — | 1 | 6.66 |
| CHEMBL212143 | — | — | 1 | 6.64 |
| CHEMBL214775 | — | — | 1 | 6.64 |
| CHEMBL211845 | — | — | 1 | 6.58 |
| CHEMBL379733 | — | — | 1 | 6.46 |
| CHEMBL215847 | — | — | 1 | 6.38 |
| CHEMBL212668 | — | — | 1 | 6.24 |
| CHEMBL209908 | — | — | 1 | 6.23 |
| CHEMBL215289 | — | — | 1 | 6.23 |
| CHEMBL215411 | — | — | 1 | 6.21 |
| CHEMBL213100 | — | — | 1 | 6.19 |
| CHEMBL215726 | — | — | 1 | 5.72 |
| CHEMBL263769 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377481 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL386760 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL215730 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL264803 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL385898 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL427047 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL211460 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL442485 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL379080 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL212721 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL212143 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL214775 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL211845 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL379733 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL215847 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL212668 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL209908 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL215289 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL215411 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL213100 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL215726 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL263769 | — | IC50 | = | 4800.0 | nM | 5.32 |