Assay Detail
Functional
CHEMBL871050
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Antiproliferative activity against LS174T cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.42 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211632 | — | — | 1 | 6.06 |
| CHEMBL213805 | — | — | 1 | 5.46 |
| CHEMBL209467 | — | — | 1 | 4.75 |
| CHEMBL213302 | — | — | 1 | 4.38 |
| CHEMBL378617 | — | — | 1 | 4.28 |
| CHEMBL211636 | — | — | 1 | 4.12 |
| CHEMBL377131 | — | — | 1 | 4.09 |
| CHEMBL212768 | — | — | 1 | 4.08 |
| CHEMBL376003 | — | — | 1 | 4.06 |
| CHEMBL213449 | — | — | 1 | 4.06 |
| CHEMBL209972 | — | — | 1 | 4.05 |
| CHEMBL211622 | — | — | 1 | 4.01 |
| CHEMBL209433 | — | — | 1 | 4.00 |
| CHEMBL374207 | — | — | 1 | - |
| CHEMBL214188 | — | — | 1 | - |
| CHEMBL213032 | — | — | 1 | - |
| CHEMBL213036 | — | — | 1 | - |
| CHEMBL214008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211632 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL213805 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL209467 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL213302 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL378617 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL211636 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL377131 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL212768 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL376003 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL213449 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL209972 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL211622 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL209433 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL374207 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL214188 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL213032 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL213036 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL214008 | — | IC50 | = | 105000.0 | nM | - |