Assay Detail
Functional
CHEMBL871055
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Antiproliferative activity against Calu1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Calu-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.68 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211632 | — | — | 1 | 5.89 |
| CHEMBL213805 | — | — | 1 | 4.94 |
| CHEMBL209467 | — | — | 1 | 4.28 |
| CHEMBL378617 | — | — | 1 | 4.19 |
| CHEMBL213302 | — | — | 1 | 4.11 |
| CHEMBL212768 | — | — | 1 | - |
| CHEMBL374207 | — | — | 1 | - |
| CHEMBL211622 | — | — | 1 | - |
| CHEMBL213449 | — | — | 1 | - |
| CHEMBL214188 | — | — | 1 | - |
| CHEMBL209433 | — | — | 1 | - |
| CHEMBL213032 | — | — | 1 | - |
| CHEMBL214008 | — | — | 1 | - |
| CHEMBL376003 | — | — | 1 | - |
| CHEMBL377131 | — | — | 1 | - |
| CHEMBL211636 | — | — | 1 | - |
| CHEMBL209972 | — | — | 1 | - |
| CHEMBL213036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211632 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL213805 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL209467 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL378617 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL213302 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL212768 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL374207 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL211622 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL213449 | — | IC50 | = | 141000.0 | nM | - |
| CHEMBL214188 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL209433 | — | IC50 | = | 147000.0 | nM | - |
| CHEMBL213032 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL214008 | — | IC50 | = | 141000.0 | nM | - |
| CHEMBL376003 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL377131 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL211636 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL209972 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL213036 | — | IC50 | = | 146000.0 | nM | - |