Assay Detail
Functional
CHEMBL871057
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Antiproliferative activity against PC3 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.35 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211632 | — | — | 1 | 6.04 |
| CHEMBL213805 | — | — | 1 | 5.21 |
| CHEMBL209467 | — | — | 1 | 4.82 |
| CHEMBL378617 | — | — | 1 | 4.44 |
| CHEMBL213302 | — | — | 1 | 4.33 |
| CHEMBL377131 | — | — | 1 | 4.26 |
| CHEMBL211636 | — | — | 1 | 4.23 |
| CHEMBL209972 | — | — | 1 | 4.18 |
| CHEMBL376003 | — | — | 1 | 4.09 |
| CHEMBL213032 | — | — | 1 | 4.07 |
| CHEMBL212768 | — | — | 1 | 4.07 |
| CHEMBL213036 | — | — | 1 | 4.05 |
| CHEMBL209433 | — | — | 1 | 4.04 |
| CHEMBL214008 | — | — | 1 | 4.04 |
| CHEMBL213449 | — | — | 1 | 4.03 |
| CHEMBL214188 | — | — | 1 | 4.03 |
| CHEMBL211622 | — | — | 1 | 4.01 |
| CHEMBL374207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211632 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL213805 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL209467 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL378617 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL213302 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL377131 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL211636 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL209972 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL376003 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL213032 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL212768 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL213036 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL209433 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL214008 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL213449 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL214188 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL211622 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL374207 | — | IC50 | = | 108000.0 | nM | - |