Assay Detail

CHEMBL871093

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Expert

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

Burgess SJ, Selzer A, Kelly JX, Smilkstein MJ, Riscoe MK, Peyton DH.
J Med Chem (2006) 49 : 5623 -5625
PubMed 16942036 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.37	8.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL209953	—	—	1	8.54
CHEMBL76	CHLOROQUINE	4.0	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL209953	—	IC50	=	2.9	nM	8.54
CHEMBL76	CHLOROQUINE	IC50	=	6.5	nM	8.19