Assay Detail
Functional
CHEMBL871113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.79 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377396 | — | — | 1 | 10.15 |
| CHEMBL211485 | — | — | 1 | 10.00 |
| CHEMBL71917 | — | — | 1 | 9.22 |
| CHEMBL1201199 | LEUPROLIDE | 4.0 | 1 | - |
| CHEMBL438652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377396 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL211485 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL71917 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1201199 | LEUPROLIDE | IC50 | - | — | - | |
| CHEMBL438652 | — | IC50 | - | — | - |