Assay Detail
Binding
CHEMBL871152
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Displacement of [3H]SR141716A from CB1 receptor in rat cerebellum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.99 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558598 | RIMONABANT HYDROCHLORIDE | — | 1 | 8.91 |
| CHEMBL307696 | — | — | 1 | 8.56 |
| CHEMBL380415 | — | — | 1 | 6.61 |
| CHEMBL383287 | — | — | 1 | 6.51 |
| CHEMBL201383 | — | — | 1 | 5.76 |
| CHEMBL381560 | — | — | 1 | 5.58 |
| CHEMBL383228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558598 | RIMONABANT HYDROCHLORIDE | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL307696 | — | Ki | = | 2.75 | nM | 8.56 |
| CHEMBL380415 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL383287 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL201383 | — | Ki | = | 1744.0 | nM | 5.76 |
| CHEMBL381560 | — | Ki | = | 2618.0 | nM | 5.58 |
| CHEMBL383228 | — | Ki | - | — | - |