Assay Detail
Binding
CHEMBL871193
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Inhibition of HIV1 recombinant integrase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.29 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50605 | — | — | 1 | 6.52 |
| CHEMBL108760 | — | — | 1 | 6.40 |
| CHEMBL209614 | — | — | 1 | 6.22 |
| CHEMBL211014 | — | — | 1 | 6.00 |
| CHEMBL210374 | — | — | 1 | 5.70 |
| CHEMBL209827 | — | — | 1 | 5.52 |
| CHEMBL208806 | — | — | 1 | 5.40 |
| CHEMBL210977 | — | — | 1 | 5.30 |
| CHEMBL210373 | — | — | 1 | 5.22 |
| CHEMBL209879 | — | — | 1 | 5.22 |
| CHEMBL377263 | — | — | 1 | 5.16 |
| CHEMBL210870 | — | — | 1 | 5.10 |
| CHEMBL209205 | — | — | 1 | 5.05 |
| CHEMBL209713 | — | — | 1 | 4.58 |
| CHEMBL210996 | — | — | 1 | 4.52 |
| CHEMBL448424 | — | — | 1 | 4.10 |
| CHEMBL210962 | — | — | 1 | 4.00 |
| CHEMBL210863 | — | — | 1 | - |
| CHEMBL379425 | — | — | 1 | - |
| CHEMBL210094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50605 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL108760 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL209614 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL211014 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL210374 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL209827 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL208806 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL210977 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL210373 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL209879 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL377263 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL210870 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL209205 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL209713 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL210996 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL448424 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL210962 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL210863 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL379425 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL210094 | — | IC50 | > | 125000.0 | nM | - |