Assay Detail
Binding
CHEMBL871199
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Inhibition of human cathepsin B
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.73 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207347 | — | — | 1 | 8.70 |
| CHEMBL378899 | — | — | 1 | 7.12 |
| CHEMBL379622 | — | — | 1 | 7.03 |
| CHEMBL405602 | — | — | 1 | 7.01 |
| CHEMBL209215 | — | — | 1 | 6.66 |
| CHEMBL209114 | — | — | 1 | 6.57 |
| CHEMBL210535 | — | — | 1 | 6.37 |
| CHEMBL209293 | — | — | 1 | 6.14 |
| CHEMBL379157 | — | — | 1 | 6.02 |
| CHEMBL208566 | — | — | 1 | 5.96 |
| CHEMBL376994 | — | — | 1 | 5.68 |
| CHEMBL209216 | — | — | 1 | 5.14 |
| CHEMBL209181 | — | — | 1 | 5.00 |
| CHEMBL210702 | — | — | 1 | 4.80 |
| CHEMBL208577 | — | — | 1 | 4.64 |
| CHEMBL210712 | — | — | 1 | 4.60 |
| CHEMBL210759 | — | — | 1 | 4.47 |
| CHEMBL210625 | — | — | 1 | 4.32 |
| CHEMBL210198 | — | — | 1 | 4.24 |
| CHEMBL211050 | — | — | 1 | 4.14 |
| CHEMBL210523 | — | — | 1 | - |
| CHEMBL209294 | — | — | 1 | - |
| CHEMBL210315 | — | — | 1 | - |
| CHEMBL378780 | — | — | 1 | - |
| CHEMBL209766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207347 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL378899 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL379622 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL405602 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL209215 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL209114 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL210535 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL209293 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL379157 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL208566 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL376994 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL209216 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL209181 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL210702 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL208577 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL210712 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL210759 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL210625 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL210198 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL211050 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL210523 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL209294 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL210315 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL378780 | — | Ki | > | 150000.0 | nM | - |
| CHEMBL209766 | — | Ki | > | 150000.0 | nM | - |