Assay Detail
Functional
CHEMBL871207
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Cytotoxicity against human H460 cell line by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.97 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612109 | — | — | 1 | 5.66 |
| CHEMBL609684 | — | — | 1 | 5.51 |
| CHEMBL352708 | — | — | 1 | 5.02 |
| CHEMBL612111 | — | — | 1 | 4.75 |
| CHEMBL609683 | — | — | 1 | 4.50 |
| CHEMBL612110 | — | — | 1 | 4.39 |
| CHEMBL609682 | — | — | 1 | - |
| CHEMBL609681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612109 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL609684 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL352708 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL612111 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL609683 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL612110 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL609682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL609681 | — | IC50 | > | 100000.0 | nM | - |