Assay Detail
Binding
CHEMBL871229
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Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
NK1 antagonists based on seven membered lactam scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.56 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425956 | — | — | 1 | 10.05 |
| CHEMBL437878 | — | — | 1 | 9.92 |
| CHEMBL380680 | — | — | 1 | 9.85 |
| CHEMBL210365 | — | — | 1 | 9.72 |
| CHEMBL209657 | — | — | 1 | 9.66 |
| CHEMBL209456 | — | — | 1 | 9.64 |
| CHEMBL210630 | — | — | 1 | 9.55 |
| CHEMBL209240 | — | — | 1 | 9.48 |
| CHEMBL209407 | — | — | 1 | 9.39 |
| CHEMBL380388 | — | — | 1 | 9.37 |
| CHEMBL378663 | — | — | 1 | 9.36 |
| CHEMBL413279 | — | — | 1 | 9.31 |
| CHEMBL382255 | — | — | 1 | 9.28 |
| CHEMBL379816 | — | — | 1 | 9.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425956 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL437878 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL380680 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL210365 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL209657 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL209456 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL210630 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL209240 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL209407 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL380388 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL378663 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL413279 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL382255 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL379816 | — | IC50 | = | 0.64 | nM | 9.19 |