Assay Detail
Binding
CHEMBL871263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CHK1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.99 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377312 | — | — | 1 | 9.49 |
| CHEMBL378967 | — | — | 1 | 9.46 |
| CHEMBL209982 | — | — | 1 | 9.30 |
| CHEMBL210639 | — | — | 1 | 8.98 |
| CHEMBL382437 | — | — | 1 | 8.85 |
| CHEMBL381952 | — | — | 1 | 8.48 |
| CHEMBL210242 | — | — | 1 | 8.48 |
| CHEMBL210035 | — | — | 1 | 8.14 |
| CHEMBL377554 | — | — | 1 | 8.12 |
| CHEMBL209256 | — | — | 1 | 7.66 |
| CHEMBL377609 | — | — | 1 | 6.86 |
| CHEMBL208937 | — | — | 1 | 6.32 |
| CHEMBL383417 | — | — | 1 | 6.14 |
| CHEMBL377345 | — | — | 1 | 5.53 |
| CHEMBL209771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377312 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL378967 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL209982 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL210639 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL382437 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL381952 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL210242 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL210035 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL377554 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL209256 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL377609 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL208937 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL383417 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL377345 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL209771 | — | IC50 | > | 30000.0 | nM | - |