Assay Detail
Functional
CHEMBL871331
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Antiproliferative activity against estrogen-dependent breast cancer MCF7 cell line by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.87 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372120 | — | — | 1 | 9.15 |
| CHEMBL196754 | — | — | 1 | 6.64 |
| CHEMBL382519 | — | — | 1 | 6.41 |
| CHEMBL378162 | — | — | 1 | 5.07 |
| CHEMBL381416 | — | — | 1 | 4.71 |
| CHEMBL103307 | — | — | 1 | 4.59 |
| CHEMBL382323 | — | — | 1 | 4.50 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372120 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL196754 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL382519 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL378162 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL381416 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL103307 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL382323 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL276711 | SEMAXANIB | IC50 | > | 50000.0 | nM | - |