Assay Detail
Binding
CHEMBL871428
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Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL4750) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Putative therapeutic agents for the learning and memory deficits of people with Down syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.88 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380093 | — | — | 1 | 5.60 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.30 |
| CHEMBL377430 | — | — | 1 | 5.30 |
| CHEMBL379386 | — | — | 1 | 5.30 |
| CHEMBL265130 | — | — | 1 | 5.00 |
| CHEMBL209699 | — | — | 1 | 4.70 |
| CHEMBL211705 | — | — | 1 | 4.70 |
| CHEMBL212045 | — | — | 1 | 4.30 |
| CHEMBL209149 | — | — | 1 | 4.30 |
| CHEMBL213905 | — | — | 1 | 4.30 |
| CHEMBL213351 | — | — | 1 | - |
| CHEMBL211756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380093 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL377430 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL379386 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL265130 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL209699 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL211705 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL212045 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL209149 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL213905 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL213351 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL211756 | — | IC50 | > | 50000.0 | nM | - |