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Assay Detail

CHEMBL871508

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Binding
Inhibition of Anthrax lethal factor activity by microplate assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372)
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.
J Med Chem (2006) 49 : 5232 -5244
PubMed 16913712 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 4.99 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215448 1 6.10
CHEMBL215449 1 5.77
CHEMBL386313 1 5.54
CHEMBL383943 1 5.52
CHEMBL115145 1 5.51
CHEMBL378575 1 5.47
CHEMBL213575 1 5.44
CHEMBL213158 1 5.44
CHEMBL212852 1 5.41
CHEMBL378860 1 5.38
CHEMBL212723 1 5.37
CHEMBL211933 1 5.36
CHEMBL386364 1 5.32
CHEMBL212406 1 5.17
CHEMBL209974 1 5.12
CHEMBL438832 1 5.11
CHEMBL379315 1 5.10
CHEMBL213144 1 5.08
CHEMBL215785 1 5.03
CHEMBL386614 1 4.98
CHEMBL385899 1 4.97
CHEMBL439545 1 4.83
CHEMBL213432 1 4.82
CHEMBL385400 1 4.80
CHEMBL386663 1 4.78
CHEMBL215771 1 4.75
CHEMBL215553 1 4.68
CHEMBL379966 1 4.67
CHEMBL441372 1 4.59
CHEMBL215644 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215448 IC50 = 800.0 nM 6.10
CHEMBL215449 IC50 = 1700.0 nM 5.77
CHEMBL386313 IC50 = 2900.0 nM 5.54
CHEMBL383943 IC50 = 3000.0 nM 5.52
CHEMBL115145 IC50 = 3100.0 nM 5.51
CHEMBL378575 IC50 = 3400.0 nM 5.47
CHEMBL213575 IC50 = 3600.0 nM 5.44
CHEMBL213158 IC50 = 3600.0 nM 5.44
CHEMBL212852 IC50 = 3900.0 nM 5.41
CHEMBL378860 IC50 = 4200.0 nM 5.38
CHEMBL212723 IC50 = 4300.0 nM 5.37
CHEMBL211933 IC50 = 4400.0 nM 5.36
CHEMBL386364 IC50 = 4800.0 nM 5.32
CHEMBL212406 IC50 = 6800.0 nM 5.17
CHEMBL209974 IC50 = 7600.0 nM 5.12
CHEMBL438832 IC50 = 7700.0 nM 5.11
CHEMBL379315 IC50 = 7900.0 nM 5.10
CHEMBL213144 IC50 = 8300.0 nM 5.08
CHEMBL215785 IC50 = 9300.0 nM 5.03
CHEMBL386614 IC50 = 10500.0 nM 4.98
CHEMBL385899 IC50 = 10700.0 nM 4.97
CHEMBL439545 IC50 = 14800.0 nM 4.83
CHEMBL213432 IC50 = 15000.0 nM 4.82
CHEMBL385400 IC50 = 15900.0 nM 4.80
CHEMBL386663 IC50 = 16500.0 nM 4.78
CHEMBL215771 IC50 = 17700.0 nM 4.75
CHEMBL215553 IC50 = 20900.0 nM 4.68
CHEMBL379966 IC50 = 21300.0 nM 4.67
CHEMBL441372 IC50 = 25600.0 nM 4.59
CHEMBL215644 IC50 = 26600.0 nM 4.58
CHEMBL215942 IC50 = 29700.0 nM 4.53
CHEMBL213533 IC50 = 29600.0 nM 4.53
CHEMBL213275 IC50 = 29900.0 nM 4.52
CHEMBL385684 IC50 = 30700.0 nM 4.51
CHEMBL213534 IC50 = 31700.0 nM 4.50
CHEMBL214303 IC50 = 35200.0 nM 4.45
CHEMBL384761 IC50 = 50000.0 nM 4.30
CHEMBL215832 IC50 = 50000.0 nM 4.30
CHEMBL215949 IC50 = 60000.0 nM 4.22