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Assay Detail

CHEMBL871509

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Binding
Inhibition of Anthrax lethal factor activity by HPLC assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372)
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.
J Med Chem (2006) 49 : 5232 -5244
PubMed 16913712 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.32 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215448 1 5.96
CHEMBL215449 1 5.75
CHEMBL115145 1 5.54
CHEMBL383943 1 5.50
CHEMBL213158 1 5.48
CHEMBL378575 1 5.43
CHEMBL212723 1 5.42
CHEMBL213575 1 5.39
CHEMBL386364 1 5.38
CHEMBL211933 1 5.33
CHEMBL212852 1 5.32
CHEMBL378860 1 5.28
CHEMBL379315 1 5.09
CHEMBL215785 1 5.06
CHEMBL438832 1 5.04
CHEMBL385899 1 5.00
CHEMBL213144 1 4.97
CHEMBL386614 1 4.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215448 IC50 = 1100.0 nM 5.96
CHEMBL215449 IC50 = 1800.0 nM 5.75
CHEMBL115145 IC50 = 2900.0 nM 5.54
CHEMBL383943 IC50 = 3200.0 nM 5.50
CHEMBL213158 IC50 = 3300.0 nM 5.48
CHEMBL378575 IC50 = 3700.0 nM 5.43
CHEMBL212723 IC50 = 3800.0 nM 5.42
CHEMBL213575 IC50 = 4100.0 nM 5.39
CHEMBL386364 IC50 = 4200.0 nM 5.38
CHEMBL211933 IC50 = 4700.0 nM 5.33
CHEMBL212852 IC50 = 4800.0 nM 5.32
CHEMBL378860 IC50 = 5200.0 nM 5.28
CHEMBL379315 IC50 = 8200.0 nM 5.09
CHEMBL215785 IC50 = 8700.0 nM 5.06
CHEMBL438832 IC50 = 9200.0 nM 5.04
CHEMBL385899 IC50 = 10000.0 nM 5.00
CHEMBL213144 IC50 = 10800.0 nM 4.97
CHEMBL386614 IC50 = 13900.0 nM 4.86