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Assay Detail

CHEMBL871510

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Binding
Binding affinity to Anthrax lethal factor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372)
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening.
Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT.
J Med Chem (2006) 49 : 5232 -5244
PubMed 16913712 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 5.67 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215448 1 6.10
CHEMBL209974 1 6.05
CHEMBL379315 1 6.05
CHEMBL212852 1 6.05
CHEMBL378575 1 5.96
CHEMBL212723 1 5.82
CHEMBL215449 1 5.80
CHEMBL386313 1 5.80
CHEMBL215785 1 5.75
CHEMBL385899 1 5.68
CHEMBL378860 1 5.62
CHEMBL115145 1 5.62
CHEMBL213158 1 5.60
CHEMBL383943 1 5.57
CHEMBL213575 1 5.54
CHEMBL386364 1 5.51
CHEMBL211933 1 5.48
CHEMBL438832 1 5.38
CHEMBL213144 1 5.27
CHEMBL212406 1 5.25
CHEMBL386614 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215448 Ki = 800.0 nM 6.10
CHEMBL209974 Ki = 900.0 nM 6.05
CHEMBL379315 Ki = 900.0 nM 6.05
CHEMBL212852 Ki = 900.0 nM 6.05
CHEMBL378575 Ki = 1100.0 nM 5.96
CHEMBL212723 Ki = 1500.0 nM 5.82
CHEMBL215449 Ki = 1600.0 nM 5.80
CHEMBL386313 Ki = 1600.0 nM 5.80
CHEMBL215785 Ki = 1800.0 nM 5.75
CHEMBL385899 Ki = 2100.0 nM 5.68
CHEMBL378860 Ki = 2400.0 nM 5.62
CHEMBL115145 Ki = 2400.0 nM 5.62
CHEMBL213158 Ki = 2500.0 nM 5.60
CHEMBL383943 Ki = 2700.0 nM 5.57
CHEMBL213575 Ki = 2900.0 nM 5.54
CHEMBL386364 Ki = 3100.0 nM 5.51
CHEMBL211933 Ki = 3300.0 nM 5.48
CHEMBL438832 Ki = 4200.0 nM 5.38
CHEMBL213144 Ki = 5400.0 nM 5.27
CHEMBL212406 Ki = 5600.0 nM 5.25
CHEMBL386614 Ki = 7200.0 nM 5.14