Assay Detail
Binding
CHEMBL871582
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Inhibition of human PI3Kgamma
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.30 |
| CHEMBL211173 | — | — | 1 | 7.70 |
| CHEMBL211819 | — | — | 1 | 7.70 |
| CHEMBL377152 | — | — | 1 | 7.54 |
| CHEMBL209159 | — | — | 1 | 7.54 |
| CHEMBL208652 | — | — | 1 | 7.52 |
| CHEMBL379156 | — | — | 1 | 7.52 |
| CHEMBL377175 | — | — | 1 | 7.43 |
| CHEMBL377104 | — | — | 1 | 7.41 |
| CHEMBL378999 | — | — | 1 | 7.40 |
| CHEMBL212119 | — | — | 1 | 7.37 |
| CHEMBL211768 | — | — | 1 | 7.25 |
| CHEMBL210991 | — | — | 1 | 7.10 |
| CHEMBL378528 | — | — | 1 | 6.96 |
| CHEMBL437688 | — | — | 1 | 6.70 |
| CHEMBL211068 | — | — | 1 | 6.58 |
| CHEMBL208662 | — | — | 1 | 6.54 |
| CHEMBL211759 | — | — | 1 | 6.42 |
| CHEMBL208696 | — | — | 1 | 6.28 |
| CHEMBL209194 | — | — | 1 | 6.08 |
| CHEMBL377337 | — | — | 1 | 6.04 |
| CHEMBL376984 | — | — | 1 | 6.02 |
| CHEMBL208866 | — | — | 1 | 5.92 |
| CHEMBL209409 | — | — | 1 | 5.58 |
| CHEMBL209560 | — | — | 1 | 5.44 |
| CHEMBL378107 | — | — | 1 | 5.42 |
| CHEMBL208780 | — | — | 1 | 5.37 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.14 |
| CHEMBL379262 | — | — | 1 | 4.87 |
| CHEMBL208977 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL211173 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL211819 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL377152 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL209159 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL208652 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL379156 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL377175 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL377104 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL378999 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL212119 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL211768 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL210991 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL378528 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL437688 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL211068 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL208662 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL211759 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL208696 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL209194 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL377337 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL376984 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL208866 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL209409 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL209560 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL378107 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL208780 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL98350 | LY-294002 | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL379262 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL208977 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL209193 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL211113 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL208698 | — | IC50 | = | 20000.0 | nM | 4.70 |