Assay Detail
Binding
CHEMBL871588
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Inhibition of human PI3Kdelta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.21 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.05 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.88 |
| CHEMBL379156 | — | — | 1 | 4.70 |
| CHEMBL208652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428496 | WORTMANNIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL379156 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL208652 | — | IC50 | > | 5000.0 | nM | - |