Assay Detail
Binding
CHEMBL871632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 2 (CHEMBL5038) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.21 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196667 | — | — | 1 | 8.43 |
| CHEMBL194408 | — | — | 1 | 8.35 |
| CHEMBL197026 | — | — | 1 | 8.33 |
| CHEMBL195635 | — | — | 1 | 8.20 |
| CHEMBL197050 | — | — | 1 | 8.19 |
| CHEMBL427540 | — | — | 1 | 8.17 |
| CHEMBL373084 | — | — | 1 | 8.17 |
| CHEMBL196581 | — | — | 1 | 8.15 |
| CHEMBL196196 | — | — | 1 | 8.08 |
| CHEMBL194837 | — | — | 1 | 8.06 |
| CHEMBL198361 | — | — | 1 | - |
| CHEMBL195351 | — | — | 1 | - |
| CHEMBL194691 | — | — | 1 | - |
| CHEMBL197245 | — | — | 1 | - |
| CHEMBL196567 | — | — | 1 | - |
| CHEMBL187756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196667 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL194408 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL197026 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL195635 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL197050 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL427540 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL373084 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL196581 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL196196 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL194837 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL198361 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL195351 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL194691 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL197245 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL196567 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL187756 | — | IC50 | > | 10.0 | nM | - |