Assay Detail
Binding
CHEMBL871633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against aromatase protein from human placental microsomes using [1-beta-3H]-androstenedione; Competitive inhibition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.55 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132530 | FORMESTANE | 2.0 | 1 | 7.38 |
| CHEMBL1629802 | — | — | 1 | 6.84 |
| CHEMBL194641 | — | — | 1 | 6.65 |
| CHEMBL1630280 | — | — | 1 | 6.17 |
| CHEMBL197451 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132530 | FORMESTANE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1629802 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL194641 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1630280 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL197451 | — | IC50 | = | 1850.0 | nM | 5.73 |