Assay Detail
Binding
CHEMBL871684
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Binding affinity for rat alpha-1 beta2/3 gamma2 GABA A / BzR receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.64 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 7.85 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 7.57 |
| CHEMBL196305 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 26.7 | nM | 7.57 |
| CHEMBL196305 | — | Ki | = | 31.0 | nM | 7.51 |