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Assay Detail

CHEMBL871772

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Binding affinity against 5-hydroxytryptamine 6 receptor of rat striatum
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Striatum
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3372)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.
Ahmed M, Briggs MA, Bromidge SM, Buck T, Campbell L, Deeks NJ, Garner A, Gordon L, Hamprecht DW, Holland V, Johnson CN, Medhurst AD, Mitchell DJ, Moss SF, Powles J, Seal JT, Stean TO, Stemp G, Thompson M, Trail B, Upton N, Winborn K, Witty DR.
Bioorg Med Chem Lett (2005) 15 : 4867 -4871
PubMed 16143522 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.90 7.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193400 1 7.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193400 Ki = 12.59 nM 7.90