Assay Detail

CHEMBL871773

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Functional

Binding affinity against 5-hydroxytryptamine 6 receptor of human caudate

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 6 (CHEMBL3371) ↗

Open DB target context

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5-hydroxytryptamine receptor 6 (CHEMBL3371) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 6

CHEMBL3371

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 6

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.

Ahmed M, Briggs MA, Bromidge SM, Buck T, Campbell L, Deeks NJ, Garner A, Gordon L, Hamprecht DW, Holland V, Johnson CN, Medhurst AD, Mitchell DJ, Moss SF, Powles J, Seal JT, Stean TO, Stemp G, Thompson M, Trail B, Upton N, Winborn K, Witty DR.
Bioorg Med Chem Lett (2005) 15 : 4867 -4871
PubMed 16143522 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.10	8.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL193400	—	—	1	8.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL193400	—	Ki	=	7.943	nM	8.10