Assay Detail
Binding
CHEMBL871846
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Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitine
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | GH4-C1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.89 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195190 | — | — | 1 | 8.96 |
| CHEMBL364069 | — | — | 1 | 8.89 |
| CHEMBL370535 | — | — | 1 | 8.74 |
| CHEMBL195345 | — | — | 1 | 8.51 |
| CHEMBL194100 | — | — | 1 | 8.47 |
| CHEMBL195329 | — | — | 1 | 8.47 |
| CHEMBL372041 | — | — | 1 | 8.39 |
| CHEMBL188469 | — | — | 1 | 8.16 |
| CHEMBL510275 | METHYLLYCACONITINE | — | 1 | 8.14 |
| CHEMBL193329 | — | — | 1 | 8.08 |
| CHEMBL365323 | — | — | 1 | 7.84 |
| CHEMBL195800 | — | — | 1 | 7.78 |
| CHEMBL194984 | — | — | 1 | 7.57 |
| CHEMBL372895 | — | — | 1 | 6.92 |
| CHEMBL365181 | — | — | 1 | 6.57 |
| CHEMBL195519 | — | — | 1 | 6.38 |
| CHEMBL440387 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195190 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL364069 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL370535 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL195345 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL194100 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL195329 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL372041 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL188469 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL193329 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL365323 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL195800 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL194984 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL372895 | — | Ki | = | 121.2 | nM | 6.92 |
| CHEMBL365181 | — | Ki | = | 268.4 | nM | 6.57 |
| CHEMBL195519 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL440387 | — | Ki | = | 524.5 | nM | 6.28 |