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Assay Detail

CHEMBL871992

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
50% loss of the monolayer present around the viral plaques in uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 1 — Organism
Curated By Intermediate

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents.
El-Subbagh HI, Abu-Zaid SM, Mahran MA, Badria FA, Al-Obaid AM.
J Med Chem (2000) 43 : 2915 -2921
PubMed 10956199 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.48 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316931 1 6.72
CHEMBL317089 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316931 IC50 = 190.0 nM 6.72
CHEMBL317089 IC50 = 580.0 nM 6.24