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Assay Detail

CHEMBL872006

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5' -monophosphate (dcAMP)
ChEMBL ↗
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Potassium-transporting ATPase (CHEMBL2095173) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Synthesis of (aryloxy)alkylamines. 1. Novel antisecretory agents with H+K+-ATPase inhibitory activity.
Sanfilippo PJ, Urbanski M, Press JB, Hajos ZG, Shriver DA, Scott CK.
J Med Chem (1988) 31 : 1778 -1785
PubMed 2842503 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 6.43 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1202672 — — 1 7.70
CHEMBL1202621 — — 1 7.30
CHEMBL1202647 — — 1 7.30
CHEMBL1202667 — — 1 7.05
CHEMBL1202658 — — 1 6.96
CHEMBL1202681 — — 1 6.92
CHEMBL1202661 — — 1 6.92
CHEMBL1202663 — — 1 6.92
CHEMBL1202656 — — 1 6.85
CHEMBL1202607 — — 1 6.85
CHEMBL1202651 — — 1 6.82
CHEMBL1202654 — — 1 6.82
CHEMBL1202668 — — 1 6.75
CHEMBL1202655 — — 1 6.68
CHEMBL1202642 — — 1 6.64
CHEMBL1202673 — — 1 6.64
CHEMBL1202615 — — 1 6.64
CHEMBL1202678 — — 1 6.62
CHEMBL1202675 — — 1 6.62
CHEMBL1202608 — — 1 6.60
CHEMBL1202643 — — 1 6.58
CHEMBL1202666 — — 1 6.58
CHEMBL1202629 — — 1 6.58
CHEMBL1503 OMEPRAZOLE 4.0 1 6.55
CHEMBL1202653 — — 1 6.51
CHEMBL1202649 — — 1 6.48
CHEMBL1202671 — — 1 6.48
CHEMBL1202648 — — 1 6.47
CHEMBL1202659 — — 1 6.47
CHEMBL1202665 — — 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1202672 — IC50 = 20.0 nM 7.70
CHEMBL1202621 — IC50 = 50.0 nM 7.30
CHEMBL1202647 — IC50 = 50.0 nM 7.30
CHEMBL1202667 — IC50 = 90.0 nM 7.05
CHEMBL1202658 — IC50 = 110.0 nM 6.96
CHEMBL1202681 — IC50 = 120.0 nM 6.92
CHEMBL1202661 — IC50 = 120.0 nM 6.92
CHEMBL1202663 — IC50 = 120.0 nM 6.92
CHEMBL1202656 — IC50 = 140.0 nM 6.85
CHEMBL1202607 — IC50 = 140.0 nM 6.85
CHEMBL1202651 — IC50 = 150.0 nM 6.82
CHEMBL1202654 — IC50 = 150.0 nM 6.82
CHEMBL1202668 — IC50 = 180.0 nM 6.75
CHEMBL1202655 — IC50 = 210.0 nM 6.68
CHEMBL1202615 — IC50 = 230.0 nM 6.64
CHEMBL1202673 — IC50 = 230.0 nM 6.64
CHEMBL1202642 — IC50 = 230.0 nM 6.64
CHEMBL1202678 — IC50 = 240.0 nM 6.62
CHEMBL1202675 — IC50 = 240.0 nM 6.62
CHEMBL1202608 — IC50 = 250.0 nM 6.60
CHEMBL1202643 — IC50 = 260.0 nM 6.58
CHEMBL1202666 — IC50 = 260.0 nM 6.58
CHEMBL1202629 — IC50 = 260.0 nM 6.58
CHEMBL1503 OMEPRAZOLE IC50 = 280.0 nM 6.55
CHEMBL1202653 — IC50 = 310.0 nM 6.51
CHEMBL1202649 — IC50 = 330.0 nM 6.48
CHEMBL1202671 — IC50 = 330.0 nM 6.48
CHEMBL1202648 — IC50 = 340.0 nM 6.47
CHEMBL1202659 — IC50 = 340.0 nM 6.47
CHEMBL1202665 — IC50 = 350.0 nM 6.46
CHEMBL1202677 — IC50 = 350.0 nM 6.46
CHEMBL1202660 — IC50 = 350.0 nM 6.46
CHEMBL1202683 — IC50 = 420.0 nM 6.38
CHEMBL1202669 — IC50 = 460.0 nM 6.34
CHEMBL50136 — IC50 = 500.0 nM 6.30
CHEMBL1202645 — IC50 = 530.0 nM 6.28
CHEMBL1202644 — IC50 = 540.0 nM 6.27
CHEMBL1202670 — IC50 = 540.0 nM 6.27
CHEMBL1202640 — IC50 = 600.0 nM 6.22
CHEMBL1202614 — IC50 = 620.0 nM 6.21
CHEMBL1202662 — IC50 = 860.0 nM 6.07
CHEMBL1202676 — IC50 = 880.0 nM 6.06
CHEMBL1202646 — IC50 = 980.0 nM 6.01
CHEMBL1202657 — IC50 = 1200.0 nM 5.92
CHEMBL300203 — IC50 = 1500.0 nM 5.82
CHEMBL50474 — IC50 = 1800.0 nM 5.75
CHEMBL1202680 — IC50 = 2000.0 nM 5.70
CHEMBL51198 — IC50 = 2600.0 nM 5.58
CHEMBL1202638 — IC50 = 2600.0 nM 5.58
CHEMBL1202641 — IC50 = 3000.0 nM 5.52