Assay Detail
Binding
CHEMBL872066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat adrenal 3-beta-hydroxy-delta-5-steroid dehydrogenase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.00 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327702 | — | — | 1 | 7.30 |
| CHEMBL314953 | — | — | 1 | 7.01 |
| CHEMBL277224 | — | — | 1 | 6.85 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327702 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL314953 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL277224 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL710 | FINASTERIDE | Ki | = | 150.0 | nM | 6.82 |