Assay Detail
Binding
CHEMBL872137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.60 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 9.08 |
| CHEMBL196258 | — | — | 1 | 6.12 |
| CHEMBL197669 | ST1535 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL196258 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL197669 | ST1535 | Ki | > | 1000.0 | nM | - |