Assay Detail
Binding
CHEMBL872272
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Compound tested for the inhibition of Staphylococcus aureus isoleucyl-tRNA synthetase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.70 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125820 | — | — | 1 | 7.40 |
| CHEMBL125075 | — | — | 1 | 7.30 |
| CHEMBL333001 | — | — | 1 | 7.00 |
| CHEMBL126515 | — | — | 1 | 6.92 |
| CHEMBL340359 | — | — | 1 | 6.89 |
| CHEMBL123796 | — | — | 1 | 6.62 |
| CHEMBL125221 | — | — | 1 | 6.57 |
| CHEMBL538163 | — | — | 1 | 6.52 |
| CHEMBL264002 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125820 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL125075 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL333001 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL126515 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL340359 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL123796 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL125221 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL538163 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL264002 | — | IC50 | = | 8000.0 | nM | 5.10 |