Assay Detail
Binding
CHEMBL872274
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Inhibition of Histone deacetylase 1 (HDAC1) of HeLa nuclear extracts
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.74 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140525 | — | — | 1 | 6.80 |
| CHEMBL336935 | — | — | 1 | 6.75 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.32 |
| CHEMBL141909 | — | — | 1 | 6.09 |
| CHEMBL343717 | — | — | 1 | 5.89 |
| CHEMBL137875 | — | — | 1 | 5.24 |
| CHEMBL337584 | — | — | 1 | 4.52 |
| CHEMBL141885 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140525 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL336935 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL141909 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL343717 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL137875 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL337584 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL141885 | — | IC50 | = | 49000.0 | nM | 4.31 |