Assay Detail
Binding
CHEMBL872293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 using [3H]Ntau(1)-Me-His-TRH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Thyrotropin-releasing hormone receptor 2 (CHEMBL3875) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | 8.00 |
| CHEMBL381666 | — | — | 1 | - |
| CHEMBL198263 | — | — | 1 | - |
| CHEMBL382714 | — | — | 1 | - |
| CHEMBL382080 | — | — | 1 | - |
| CHEMBL369944 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1472 | PROTIRELIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL381666 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL198263 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL382714 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL382080 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL369944 | — | Ki | > | 100000.0 | nM | - |